Doris Benbrook, PhD

Accepting PhD Students

  • 3355 Citations
  • 31 h-Index
1986 …2018
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Projects 1999 2011

Mechanism of SHeA2 Action in Ovarian Cancer

Benbrook, D.

National Institutes of Health

6/1/054/30/11

Project: Research projectResearch Project

Ovarian Neoplasms
Retinoids
Apoptosis
N-acetylglucosamine-6-sulfatase
(((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione

Steroids and Stem Cell in Carcinogenesis

Benbrook, D.

National Institutes of Health

9/30/038/31/06

Project: Research projectSmall Research Grants

Chemoprevention
Carcinogenesis
Stem Cells
Steroids
Animal Models

MECHANISM &POTENTIAL OF RETINOID &DNA DAMAGE THERAPY

Benbrook, D.

National Institutes of Health

7/1/996/30/04

Project: Research projectResearch Project

Research Output 1986 2018

  • 3355 Citations
  • 31 h-Index
  • 96 Article
  • 1 Chapter

Anti-CD73 and anti-OX40 immunotherapy coupled with a novel biocompatible enzyme prodrug system for the treatment of recurrent, metastatic ovarian cancer

Virani, N. A., Thavathiru, E., McKernan, P., Moore, K., Benbrook, D. M. & Harrison, R. G., Jul 1 2018, In : Cancer Letters. 425, p. 174-182 9 p.

Research output: Contribution to journalArticle

Prodrugs
Ovarian Neoplasms
Immunotherapy
Cystathionine gamma-Lyase
Enzymes

Correlation of clinical data with fallopian tube specimen immune cells and tissue culture capacity

Ramraj, S. K., Smith, K. M., Janakiram, N. B., Toal, C., Raman, A. & Benbrook, D. M., Jun 1 2018, In : Tissue and Cell. 52, p. 57-64 8 p.

Research output: Contribution to journalArticle

Fallopian Tubes
Cell Culture Techniques
Epithelial Cells
Interleukin-10
Macrophages

Pharmacokinetics and interspecies scaling of a novel, orally-bioavailable anti-cancer drug, SHetA2

Sharma, A., Benbrook, D. M. & Woo, S., Apr 1 2018, In : PLoS One. 13, 4, e0194046

Research output: Contribution to journalArticle

Slip forming
antineoplastic agents
pharmacokinetics
Pharmacokinetics
dosage
3 Citations

A stratified randomized double-blind phase II trial of celecoxib for treating patients with cervical intraepithelial neoplasia: The potential predictive value of VEGF serum levels: An NRG Oncology/Gynecologic Oncology Group study

Rader, J. S., Sill, M. W., Beumer, J. H., Lankes, H. A., Benbrook, D. M., Garcia, F., Trimble, C., Tate Thigpen, J., Lieberman, R., Zuna, R. E., Leath, C. A., Spirtos, N. M., Byron, J., Thaker, P. H., Lele, S. & Alberts, D., May 1 2017, In : Gynecologic Oncology.

Research output: Contribution to journalArticle

Celecoxib
Cervical Intraepithelial Neoplasia
Vascular Endothelial Growth Factor A
Placebos
Serum

Development of a dietary formulation of the SHetA2 chemoprevention drug for mice

Benbrook, D. M., Janakiram, N. B., Chandra, V., Pathuri, G., Madka, V., Stratton, N. C., Masamha, C. P., Farnsworth, C. N., Garcia-Contreras, L., Hatipoglu, M. K., Lighfoot, S. & Rao, C. V., Dec 22 2017, (Accepted/In press) In : Investigational New Drugs. p. 1-10 10 p.

Research output: Contribution to journalArticle

Formulated Food
Chemoprevention
Cyclin D1
Pharmaceutical Preparations
Kidney Function Tests